Each clue can be answered with a phrase that can also be interpreted as a cryptic crossword style indicator for a letter:
FIRST AMENDMENT - A
HONDA CENTER - N
BUS TERMINAL - S
THIRD DOWN - W
END ZONE - E
QUARTERFINAL - R
INITIAL PUBLIC OFFERING - P
MIDDLE OF NOWHERE - H
FINAL FANTASY - Y
FOURTH CRUSADE - S
SECOND WIND - I
HEAD COUNT - C
LAST OF THE MOHICANS - S
These letters spell ANSWER PHYSICS.